Consider the given two statements:
I: | In competitive enzyme inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time. |
II: | The inhibitor always has a much higher affinity for the active site than the normal substrate. |
1. | Both I and II are correct and II explains I |
2. | Both I and II are correct but II does not explain I |
3. | I is correct but II is incorrect |
4. | I is incorrect but II is correct |
Assertion (A): | Malonate is a competitive inhibitor of succinic dehydrogenase enzyme. |
Reason (R): | Malonate has a structure similar to fumarate, the product of succinate oxidation, and thus binds to the active site of succinic dehydrogenase. |
1. | Both (A) and (R) are True and (R) correctly explains (A). |
2. | Both (A) and (R) are True but (R) does not correctly explain (A). |
3. | (A) is True but (R) is False. |
4. | (A) is False but (R) is True. |